Tag Archives: Startup company

Startup Medical Devices Change the World

RDN Procedure 2 - Catheter-based Energy DeliveryIn case you aren’t paying attention, novel medical devices are changing the world. Some recent clinical trial headlines:

Ardian’s Renal Denervation System Demonstrates Sustained Blood Pressure Reduction at 30 Month Follow Up

Asthmatx Bronchial Thermoplasty Provides Long Term Asthma Control Out to 5 Year Follow Up

Percutaneous Valve Technologies’ and CoreValve’s Real World Registry Data Show That Transcatheter Valves Dramatically Improve New York Heart Association class III/IV symptoms and Angina

Barrx’s Endoscopic Ablation Therapy Eliminates Precancerous Esophageal Tissue and Significantly Reduces Disease Progression In Patients with Low Grade Dysplasia

EndoGastric Solutions’ Incisionless Endoscopic Procedure Significantly More Effective at Eliminating Chronic GERD Symptoms than Maximum PPI Dose, New Data Show

CV Ingenuity’s drug-eluting balloon demonstrates good 12 month efficacy in peripheral arterial disease.

Making a real and lasting impact – that’s what medical device startups are all about.

That’s why I do what I do.

Medical Device Venture Funding Trends – Q1 2013

PWCMoneyTree Medical Device Venture Investments 1995-2013The latest quarterly MoneyTree Report was just released, providing some insight into the state of medical device venture funding in the US. I downloaded and plotted the historical trend data for medical device VC investments in the U.S. from Q1 1995 to Q1 2013.  Click on the thumbnails for larger images.

What do the trends tell us?

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Uncle Bob Describes The Start-Up Trap

Uncle Bob

My colleague Jeff shared a great blog post recently, “The Start-Up Trap” by Uncle Bob. While the post is ostensibly about coding, the philosophy applies broadly.

Definitely worth checking out.

Medical Device Startups – Northern California Over New England Again

NE Medical Device Startups 2012Q4In the eight years of data I’ve collected on New England medical device company venture funding, I’ve never seen it this tough. Only four new companies were funded in 2012 (see my complete list below).

You might be tempted to blame VC belt-tightening  or the “Patient Protection and Affordable Care Act.” You’d be wrong.  While the macro environment has its challenges, four new NorCal medical device startups were funded in Q4 alone.

What gives?

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Medical Device Marketing – Segmentation With Procedure Data

Portrait of Jan de Doot and the kidney stone h...

Ask most medical device marketers about market segmentation, and you’ll get an earful about physician specialty (and subspecialty), hospital/facility size or type (academic, ASC, for profit, large system, etc), or adopter type (early adopters, followers, and skeptics). Unfortunately, these approaches rarely help companies identify customer groups that are differentially addressable – i.e. best served by different products or services, different price points, and/or different marketing channels and sales techniques.

Contrast the typical medical device approach to the sophisticated techniques of consumer product firms. Are you a Barry, Jill, Buzz, Ray, or Mr. Storefront? Best Buy’s in-store staff segments you with a few questions before steering you to the products you’re most likely to want. Amazon suggests possible purchases for you, based on your clicks plus the buying history of other customers who bought the same products you did. Target buys your demographic data to combine with your Target purchase history to create custom coupons for you.

Medical device firms can do much, much more to understand and better serve their markets. Even back in the 1980′s much more could be done. Let me explain how I approached market segmentation twenty-something years ago.

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Healthcare Venture Capital Fundraising List 2012 Q4

Time Is TightThe glass is half full. I’ve been tracking the fundraising activity of healthcare venture firms for the last few years, and I estimate that there are about 250 VC firms actively investing in healthcare innovation worldwide. In contrast, a list I created ten years ago, at InfraReDx, included about 500 healthcare VC firms. Times are tight in 2013.

Why the drop?

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Star Medical Device Engineer – Attitude

Engineering Department employees, 1962

Engineering Department employees, 1962 (Photo credit: Seattle Municipal Archives)

One of the best parts of starting a medical device company is the opportunity to build a great team. At Fractyl, I’m happy and proud to say that our team is truly awesome – talented, hardworking, committed, and fun. Putting together a great team is not easy – for every position, we’re always looking for a superstar. Somehow we’ve found them.

One of my best friends runs an engineering group at a major contract research lab, and we occasionally commiserate about the difficulty of hiring great engineers. Of course, number one on our list is technical expertise. Don’t knock on my door if you don’t have the technical chops. While technical competence is hard enough to find, my friend and I are both looking for more than mere technical brilliance. The number two attribute on my list of star medical device engineers is attitude.

In an effort to improve performance, my friend gives each of his engineering hires an article from 1999′s IEEE Spectrum: “How to be a Star Engineer” (or here).  It’s a great article that would benefit almost every engineer. The author, Robert Kelley, presents nine strategies that lead to better engineering performance. Attitude is critical.

Here’s the attitude I’m looking for:

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Bits and Atoms

atoms to bits

atoms to bits (Photo credit: Will Lion)

More than two million drug-eluting stents were sold worldwide in 2011, of which 87% were manufactured from just five product designs [source]. The success or failure of product development is ultimately measured by financial outcomes. Each of us hopes our large investments in product development will be returned many times over by the sale of millions of profitable manufactured units.

A great product design is thus the set of instructions that enables scalable, salable, profitable production.

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Typical Life Science Merger and Acquisition Terms

Payday Loan Place Window Graphics

Payday (Photo credit: taberandrew)

I’ve written about unusual deal terms before (here and here), but Bruce Booth’s awesome blog Life Sci VC just introduced me to a great new report on typical life science deal terms. While the big headline is that 83% of life science deals include earn-outs, I was surprised to learn that the average amount of equity invested in medical device companies prior to exit was $60M (median $44M). Senior medical device startup execs should definitely read Booth’s article and download the full report.

Read Booth’s post here.

Download the study here.

Read the press release here.

Press coverage on PE Hub here.

Healthcare Venture Capital Fundraising List 2012 Q2

 

Sanger Institute and Hinxton Hall, Cambridge, UK

Sanger Institute and Hinxton Hall, Cambridge, UK (Photo credit: Wikipedia)

It’s been several months since I’ve updated my list of “Healthcare VC’s with money to invest,” so I have plenty to report.

I’ve added about 35 new announcements of firms that successfully raised new funds or are actively raising new funds. Most VC firms that are actively raising new funds are simultaneously looking for investment opportunities, so they will be positioned to put their new money to work right away. Definitely consider pitching them.

While there are a few really small funds (under $100M), the majority of healthcare-focused firms seem to target a$150M to $300M fund sizes. A handful of diversified firms have also raised new funds. While diversified firms are typically larger, it’s important to remember that the healthcare portion is just one piece, and may not be bigger than the healthcare-focused funds.

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